If you knew what you were doing I would say "sure go ahead and put together the ugliest ass piece of crap you have ever seen".
If you dont know what your doing dont do it.
If you have a shred of pride live with a single sub or run matching subs, or your nickname will either be "smokey" or "ghetto install boy"
You should live a long happy life with a single sub (if it is a common chamber box you could leave the dead sub in there to hide the hole)